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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are typically described as a focus on the practical aspects of design that include the recruitment process and consent, adhering and the use of routinely available equipment.

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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be reliable and lessen the chance of bias is also essential. However, too much heterogeneity can cause issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policymakers and practitioners in order to inform their decisions. They also provide a useful method to determine the causality between an intervention and 프라그마틱 슬롯 사이트 its results. However, they should not, be used to replace explanatory studies.

The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they are an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a practical trial that include the recruitment process, the design and implementation of the intervention, and the follow-up.

There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.