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Pragmatic trials are studies designed to provide information for real-world clinical practice. They are often described as a focus on the practical aspects of study design that include the recruitment process and consent, adhering and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from different geographical regions. This kind of heterogeneity is required for practical trials to be valid and also helps reduce bias in the results. However, too much heterogeneity can cause issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually requested by practitioners and policymakers in order to guide their decisions. They are also a good way to identify the causal relationship between the intervention and its effects. However, they should not be used to substitute for the use of explanation studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which guide the practice and policy decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial which includes recruitment, design and delivery of the intervention, as well as follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), 프라그마틱 슬롯무료 무료 슬롯, Optimusbookmarks.Com, 프라그마틱 무료 returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the issue of pragmatics. It is important to note that the majority of these studies were conducted in primary care settings.