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Pragmatic trials are trials designed to inform real-world clinical practice. They are usually characterized by a focus on practical aspects of the study design, such as the recruitment process and consent as well as adherence to the use of commonly available equipment.

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Pragmatic is a software company provides a variety of casino games on online gambling platforms. Pragmatic's iGaming software is used by leading operators and land based casinos. The company offers front-end site design tools, analysis tools and promotions, marketing security payment systems, customer support and bug-reporting. Additionally, the company offers its players a secure environment with high-quality graphics and games.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and participants from various geographical areas. This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, a major player on the live casino market, provides an array of traditional table games such as Blackjack and Roulette. The company's live studios in Romania and Malta offer a real-life gambling experience for players, as well as an extensive selection of virtual betting options. The company also has several game shows that make online gambling fun and interactive. Some of these shows are broadcast live and others are hosted by famous personalities from the field.

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Legality

Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. The software is available on mobile devices and in a variety of languages. It has been recognized as one of the most popular casino gaming platforms despite its relative youth. The most recent releases include Wolves, a 5-reel video slot that has a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually requested by policy makers and practitioners to guide their decision-making. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used to substitute for explanation studies.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool attempted to define the features of a practical trial, including the recruitment process, the design and implementation of the intervention, and monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatics. It is important to note that the majority of these trials were conducted in primary care settings.