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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of designing a study that include the recruitment process and consent, adhering and the use routinely available equipment.

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Pragmatic is a software developer that provides a variety of casino games for online gambling platforms. Pragmatic's iGaming software is used by the top operators as well as land-based casinos. The company offers front-end design tools, analysis tools, promotions, marketing payment systems, security, customer service and bug reporting. Additionally, the company offers its players a secure environment with high-quality graphics as well as games.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from various geographical areas. This kind of heterogeneity, that is crucial for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However excessive heterogeneity could cause problems with the design of the trial.

Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market offers an array of traditional table games like Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta offer a real-life gambling experience for players and offer an extensive selection of virtual betting options. The company also hosts a variety of games that make online gambling exciting and interactive. Some of these shows are broadcast live and some are hosted by famous personalities from the field.

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Legality

Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is designed to work on mobile devices and is compatible with different languages. Despite its relatively young age, it has already established itself as a leading gaming platform for casinos. The latest releases include Wolves 5 reel video slot with a healthful RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. They are usually requested by practitioners and policy makers to inform their decision making. They also provide a useful method of determining the causality between the intervention and its effects. However, they shouldn't be used as a substitute for explanatory studies.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they are an addition to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic study that include the recruitment process, the design and delivery of the intervention, and monitoring.

The number of pragmatic trials is increasing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.